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In recent newsletter articles I have discussed the significant growing health issue of NAFLD – Non-Alcoholic Fatty Liver Disease which is now present in approximately 25% of the general population.

From the website: GMWatch.org:

“Risk factors for NAFLD include being overweight or obese, having diabetes, or having high cholesterol or high triglycerides (a constituent of body fat) in the blood. However, some people develop NAFLD even if they do not have any of these known risk factors.

Symptoms of NAFLD include fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain, spider-like blood vessels, yellowing of the skin and eyes (jaundice), itching, fluid build-up and swelling of the legs and abdomen, and mental confusion”.

Excessive consumption of sugar – especially fructose can also contribute to the development of NAFLD.

Another potential cause of the dramatic increase in the incidence of NAFLD in the general population is exposure to glyphosate, present in the herbicide Roundup:

From the same article mentioned above from GMWatch.org:

Roundup causes non-alcoholic fatty liver disease at very low doses

“The weedkiller Roundup causes non-alcoholic fatty liver disease at very low doses permitted by regulators worldwide, a new peer-reviewed study shows. The study is the first ever to show a causative link between consumption of Roundup at a real-world environmentally relevant dose and a serious disease”.

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Trying to understand why we need to sleep has been a topic that researchers have been pursuing for many decades: why do we spend approximately 1/3 of our lives sleeping?

There has been some very interesting research published in the last several years which helps to give us some insight into this intriguing question.

I recently listened to a podcast on the topic of sleep in which Peter Attia, MD was interviewing Matthew Walker, PhD professor of neuroscience at UC Berkeley and an expert on sleep.

Info on Peter and his podcast are included at the end of this article.

This was a lengthy interview: some three hours so it has been broken down into three podcasts.

I came away from listening to these podcasts completely reshaping my understanding of the health impact of adequate sleep: the rapidity of cognitive and performance deterioration after even one night of poor sleep is shocking.

One of the topics that I found most interesting was the link between sleep deprivation and the potential development of Alzheimer’s.

A recent discovery is the existence in the brain of the “Glymphatic System”.

Glymphatic of course sounds similar to Lymphatic – and that is a good comparison in that the Glympatic system functions in the brain like the Lymphatic system functions in the body.

How this impacts on Alzheimer’s is as follows:

Amyloid proteins are present in everyone’s brain, and what happens during sleep is these amyloid proteins are transported out of the brain by the Glympatic system.  If sleep duration is compromised, the clearing effect is diminished which can lead to an accumulation of amyloid proteins.

And of course Alzheimer’s is a complex disease process so like many other factors, lack of sleep may be a contributing factor to the development of Alzheimer’s.

We have all heard of individuals who boast of being able to get by on restricted sleep: five hours or whatever.

Matt in one of the podcasts made reference to two high profile politicians from the past that boasted about this, and lived their lives in this manner (restricted hours of sleep).

These two individuals were Ronald Regan and Margaret Thatcher, both of whom ended up developing dementia/Alzheimer’s in the latter stages of their lives.

In conjunction with these podcasts, I also came across an article published in the Natural Medicine Journal:

Sleep Deprivation and Alzheimer’s Disease:

I don’t know about you, but I think I am going to bed early tonight…

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Some recent dietary and eating pattern trends have been shown to have positive benefits on health for many individuals.

The specific trends I am referring to include: low carb diets, intermittent fasting and compressed windows of feeding (such as 8/16 hours: eating during  a period of 8 hours and fasting for 16 hours.)

The following article from Natural News highlights some of the recent studies and health benefits of intermittent fasting.

I am sure many of you may have tried intermittent fasting yourselves and have recommended it to your patients: I certainly count myself in with this group, and I have seen some significant health benefits in some patients.

In the article, it highlights a specific study done at Harvard which was published in the journal Cell Metabolism.

Here is one of the key takeaways from the study:

“Manipulating mitochondrial networks inside cells — either by dietary restriction or by genetic manipulation that mimics it — may increase lifespan and promote health, according to new research from Harvard T.H. Chan School of Public Health.”

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Further published research supports the fact that dietary fat consumption does NOT cause Heart Disease: A recently published meta-analysis (analysis of multiple published studies) supports this. The original research suggesting that dietary (saturated) fat contributed to heart disease fat which is described as the “Diet/Heart (Disease) Hypothesis” was flawed (the original researcher Ancel Keys, selectively chose data results which supported his hypothesis and excluded considerable data which showed it was not true!

Here is a summary on this recent analysis:

New Evidence Reveals that Saturated Fat Does Not Increase the Risk of Cardiovascular Disease

In light of new scientific data, it appears that saturated fat is not associated with an increased risk of cardiovascular disease (CVD).
Andrew Mente Andrew Mente, PhD

Highlights

Assistant Professor, Department of Clinical Epidemiology and Biostatistics, McMaster University

Present evidence suggests that saturated fat does not increase the risk of cardiovascular disease.
No causal relationship has been established between milk products and cardiovascular risk.
Factors associated with an increased risk of coronary heart disease include trans fatty acids and high glycemic-index foods.

Part of the confusion comes from the food and processed oils industry creating misinformation to confuse the general public.

Note the last point in the summary: high glycemic-index foods are carbohydrates/sugars which can be a major contributor to not only heart disease but also diabetes, non-alcoholic fatty liver disease etc. https://www.dairynutrition.ca/…/new-evidence-reveals-that-s…

Today I want to share with you an excellent in depth article from the blog of Dr. Gabriel Cousins, MD. which discusses the disastrous advent of 5G wireless technology.

This technology is predicted to create significant health issues for humanity: from the article below, here are some of the suggested consequences.

Effects include:

Damage goes well beyond the human race, as there is abundant evidence of harm to diverse plant- and wildlife[xl] [xli] and laboratory animals, including ants,[xlii] birds,[xliii] [xliv] forests,[xlv] frogs,[xlvi] fruit flies,[xlvii] honey bees,[xlviii] insects,[xlix] mammals,[l] mice,[li] [lii] plants,[liii] rats,[liv] trees,[lv] and microbes.[lvi]

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Copyright © 2019 R. V. Lamberton & Associates, All rights reserved

Genetic mutations (polymorphisms) of the MTHFR (methylenetetrahydrofolate) enzyme are common in the general population.

Estimates are that approximately 60% of the general population (including myself) possess this mutation which comes with a range of influence on such important metabolic processes as methylation* pathway impairment, the potential buildup of homocysteine levels etc.)

* For those of you who read my newsletter that are not health care practitioners here is a simple explanation of methylation from the website: Mindbodygreen:

What is methylation? Without getting too technical, methylation is the addition of a single carbon and three hydrogen atoms (called a methyl group) to another molecule. The removal of a methyl group is called demethylation. Think of billions of little on/off switches inside your body that control everything from your stress response and how your body makes energy from food, to your brain chemistry and detoxification. That’s methylation and demethylation.

Typically if the MTHFR polymorphism is negatively impacting on methylation function, one of the approaches to improve this is for the individual to supplement with 5-methyltetrahydrofolate (5-methyl THF) – which is something that I personally do.

The reason this is done is that with this polymorphism the biochemical pathway step which involves converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-methyl THF), the primary circulatory form of folate utilized in homocysteine remethylation to methionine is impaired.  By consuming the end product – 5-methyl THF you are consuming the end product and not worrying about the impaired conversion to make the end product – 5-methyl THF.

The following article suggests that by simply supplementing with Riboflavin (Vitamin B2) that the additional Riboflavin can make the enzyme necessary for this conversion to work like normal.

Supplementing with 5-methyl THF certainly works, however many readers I am sure would agree that targeting and resolving the cause of the problem
(the enzymatic conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-methyl THF) makes more sense – rather than targeting the effect.

In addition,  5-methyl THF is typically a practitioner grade supplement which the general population would not typically have access to – and most in this population would not understand the biochemistry/biochemical pathways involved and may actually exacerbate an existing problem (for example, initiating overmethylation can disrupt neurotransmitter balance).  Also 5-methyl THF is much more expensive vs. Riboflavin, a common and accessible B vitamin.

Many comprehensive B vitamin complexes may in fact have enough Riboflavin content to meet this need, and I am of the opinion that it is always best to take balanced ratios of the B vitamins – unless there is a specific identified need for a larger amount of a specific B vitamin(s).

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Copyright (C) 2019 R. V. Lamberton & Associates All rights reserved.