Category: Brain Health / Conditions

One of the major issues causing problems with losing weight and maintaining a healthy weight is due to the presence of chemicals in the body – environmental toxins.

Some of these chemicals are called “obesogens” – because they cause obesity and it is almost impossible for an individual to lose weight until these compounds are removed.

A key compound in this category is phthalates, often referred to as plasticizers.

Weight issues for individuals have reached epidemic proportions across the world – in the U.S. alone, 39.8% of adults aged 20 and over are obese.

Historically, the suggested solution to this significant issue was to eat less and exercise more – in fact this is the advice that most MDs will currently suggest to their patients who are struggling with weight issues.

Losing weight and maintaining a healthy weight is certainly not as simple as eating less and exercising more, although these factors can provide benefits.

Other factors may include, and this is certainly not an exhaustive list the following – hormonal imbalance, including elevated cortisol levels, inflammation, genetic mutations, a diet which includes poor quality food sources, lack of sleep, stress and many more.

The way to rid the body of these chemicals is through a supervised detox program.

This should be done under the supervision of a health care practitioner knowledgeable in this area as freeing up these chemicals can cause significant problems if the body has not been prepared properly to excrete these chemicals.

Following is an article published by Functional Medicine University which discusses this topic.

Difficulty Losing Fat? This May Be the Cause

Ronald Grisanti D.C., D.A.B.C.O., DACBN, MS, CFMP

Obesity has hit epidemic proportions and the world is desperate to do anything to lose their unwanted fat.

Although eating a healthy diet and exercise is paramount to losing fat, there is one little unknown fact that will prevent millions of people from ever losing fat.

According to the US government this one thing is the considered the number one pollutant in the human body and will put a quick halt to ever reaching your desired level of fitness and fat loss.

One of the major causes of the obesity epidemic is the unprecedented level of phthalates or plasticizers.

The problem with these toxic environmental toxins is the fact that they are difficult to impossible to avoid. In fact they are found in every species even in the most pristine wild.

In fact we have so damaged the chemistry of even animals in the wild that the polar bears in the Arctic have human diseases such as hypothyroidism and osteoporosis.

Phthalates are the highest pollutant in the body being over 10,000 times higher than any of the thousands of other environmental toxins.

In fact they are so pervasive that now children six years of age have levels that used to take adults until the age of 40 to accumulate.

Phthalates are the highest pollutant in the body being over 10,000 times higher than any of the thousands of other environmental toxins.

Phthalates are the highest pollutant in the body being over 10,000 times higher than any of the thousands of other environmental toxins.

The government agencies, scientific and medical literature have clearly documented that a huge amount of these environment toxins (phthalates) come from our water, soda and infant formula bottles, food packaging, cosmetics, nail polish, mattresses, couches, carpets, clothing, medications, styrofoam cups, IVs, vinyl flooring, construction materials, home wiring, computers, industrial and auto exhausts, etc.,

The sad point is the fact that these toxins stockpile in the body and overwhelm our ability to detoxify them.

We routinely measure them with a wonderful test called Phthalates & Parabens Profile (https://www.gdx.net/product/phthalates-parabens-test-urine)

In addition to the damage these environmental toxins do to the biochemistry of losing fat they have also been known to be associated with difficult to treat chronic fatigue syndrome,fibromyalgia, ADD,  syndrome X, diabetes, arteriosclerosis, allergies, and much more.

In fact the label that a disease has is now unimportant. All we care about is what caused the disease and what biochemical corrections are necessary to get rid of it and actually bring about a true solution, a word you rarely hear in drug-oriented medicine.

What is even worse is the fact a pregnant mother’s phthalate levels (look at how many are continually drinking from plastic water bottles, etc., thinking that it’s something healthful) hugely influence not only the development of the child’s brain and glands, but even future fertility and cancers in their unborn children, not to mention, of course, obesity.

What you need to understand and something the researchers have forgot to mention is the fact that fat stores a huge amount of our chemicals, so the fatter you are the more the difficult it is to lose fat. Interesting and at the same time depressing.

The bottom line is many people will never lose weight or solve their medical problems because they have not gotten rid of the phthalates and other environmental pollutants that have damaged their chemistry and genetics.

One of the key ingredients to ridding the body of these harmful toxins is first to do what you can to avoid it (STOP DRINKING OUT OF STYROFORM CUPS and PLASTIC BOTTLES) and invest in a far infrared sauna

References:

Heindal JJ, Endocrine disruptors and the obesity epidemic, Toxicol Sci 76; 2:247-49, 2003

Baillie-Hamilton PF, Chemical toxins: a hypothesis to explain the global obesity epidemic, JAIt Complement Med 8;2:185-92, 2002

Alonso-Magdalena P, et al, The estrogenic effect of bisphenol A disrupts pancreatic B-cell function in vivo and induces insulin resistance, Environ Health Perspect 114:106-12, 2006

The Hundred Year Diet in the Wall Street (May 10, 2010, A I5)

Vom Saal FS, Welshons WV, Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A, Environ Res, 100;1:50-76, Jan. 2006

Feige JN, et al, The endocrine disruptor monoethyl-hexyl phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis, JBiol Chem 282:19152-66, 2007

Hatch EE, et al., Association of urinary phthalate metabolite concentrations with a body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002, Environ Health 7:27, 2008

Clark K, et al, Observed concentrations in the environment. In: The Handbook of Environmental Chemistry. Vol 3, Part Q. Phthalate Ester (Staples CA, ed). New York: Springer, 125-177, 2003

Feige JN, et al, The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARa-dependent mechanisms, Environ Health Persp, 118; 2:234-41, Feb 2010

Jaakkola JJK, et al, The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: A systematic review and meta-analysis, Environ Health Perspect 116:845-53, 2008


A recent documentary viewed by many suggested that a plant based – vegan diet is the optimal diet for athletes.

What Is The Game Changers?

The Game Changers is an agenda-driven film, not an objective analysis of an optimal diet for athletes. The purpose of this film is to advocate for a plant-based diet. It hasn’t been peer-reviewed, and it plays very fast and loose with the science. It’s propaganda for veganism, pure and simple. 

This is a very slick, well-done film, and it has the potential to mislead a lot of people. But it’s full of misleading statements, half-truths, flat-out falsehoods, flawed logic, and absurdities.

Chris Kresser of ChrisKresser.com did a great rebuttal of this documentary – both live on two podcasts on the Joe Rogan show as well as in writing.

Below is a portion of his written comments.

The documentation is quite extensive so if you want to review it in detail here is the link.

As a health care practitioner dealing with clients to help them with their health issues I will suggest that a vegan diet typically ends up over time in causing negative health issues, typically due to vitamin and mineral deficiencies.

My experience is similar to most health care practitioners whom I ask about this topic.

No one diet is optimal for everyone!

Determining an optimal diet is best done by working with a knowledgeable health care practitioner such as an integrative/Functional Medicine MD, ND, DC, RD, nutritionist etc.

Here is the initial part of Chris’s written rebuttal to The Game Changers documentary.

What is the optimal diet for athletes? While I don’t believe there is one optimal diet for every person, I do think there are characteristics that all healthy diets share. Namely, they’re ancestral—based on the types of foods that our bodies evolved to thrive on—and they include a mix of nutrient-dense plant and animal foods.

A recent documentary called The Game Changers claims otherwise. The experts and celebrities featured in the film argue that a plant-based, vegan diet is optimal for athletes and that animal foods are harmful for athletic performance and overall health.

There are a lot of myths and misconceptions on this topic, so I wanted to take this opportunity to debunk some of the biggest claims made in The Game Changers. For a full breakdown of what this movie gets wrong, download my Show Notes, and listen to my appearance on The Joe Rogan Experience.


I’ve conducted extensive research on the real impact of a plant-based diet over an omnivorous, ancestral diet. I’m sharing that research with you now in hopes that it helps clear up some of the misconceptions on vegan diets.

What Is The Game Changers?

The Game Changers is an agenda-driven film, not an objective analysis of an optimal diet for athletes. The purpose of this film is to advocate for a plant-based diet. It hasn’t been peer-reviewed, and it plays very fast and loose with the science. It’s propaganda for veganism, pure and simple. 

This is a very slick, well-done film, and it has the potential to mislead a lot of people. But it’s full of misleading statements, half-truths, flat-out falsehoods, flawed logic, and absurdities. I found problems with a number of claims made in the movie, including:

  • The gorilla analogy
  • The idea that peanut butter has as much protein as beef or eggs
  • The gladiator diet
  • The impact of protein on strength and health
  • Where B12 comes from

These are examples of some very misleading and disingenuous uses of science.

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Today I want to share with you a paper I recently came across which documents the benefits of Resveratol supplementation.

Resveratrol is a key ingredient in our Integra Nutrition Longevity Sciences GenZogenol-R formulation which was designed to target the aging process at the DNA level.

You can find out more about the GenZogenol-R formulation on the Integra Nutrition website – or contact me directly:

Phone: 778-227-4952

Email: Rob@RobLamberton.com

In addition to Resveratrol we have included in the GeZogenol formulation Pterostilbene which is often described as a “Methylated Resveratrol”.

Resveratrol and Pterostilbene work synergistically when taken together however there are some significant differences between them:

“Pterostilbene is described as a methylated resveratrol which has a much longer half life vs. resveratrol: 14 minutes for resveratrol vs. 105 minutes for pterostilbene, pterostilbene is also more bioavailable – 80% vs. resveratrol – 20%. better metabolic activity vs. resveratrol, it is also a (PPARа) agonist.”

This paper describes how Resveratrol “Prolongs Lifespan And Delays Onset Of Aging-related Traits”.

Following is an article from Science Daily on this paper as well as a link to the paper.

From the paper:

“Resveratrol appears to be the first molecule to consistently cause life extension across very different animal groups such as worms, insects, and fish, and it could become the starting molecule for the design drugs for the prevention of human aging-related diseases”.

Regards,

Rob

Natural Compound Prolongs Lifespan And Delays Onset Of Aging-related Traits In A Short-lived Vertebrate

Summary: By studying a particularly short-lived fish species, researchers have been able to show that a natural compound previously shown to extend lifespan in non-vertebrate organisms can also do so in at least one vertebrate species. The findings, reported by Alessandro Cellerino of the Scuola Normale Superiore, Pisa, and colleagues, support the potential utility of the compound in human aging research.

FULL STORY


By studying a particularly short-lived fish species, researchers have been able to show that a natural compound previously shown to extend lifespan in non-vertebrate organisms can also do so in at least one vertebrate species. The findings, reported by Alessandro Cellerino of the Scuola Normale Superiore, Pisa, and colleagues, support the potential utility of the compound in human aging research.

The development of drugs able to retard the onset of aging-related diseases and improve quality of life in the elderly is a growing focus of aging research and public health in modern society. But the successful development of drugs aimed at aging-related diseases needs to face the challenge posed by the lifespan of the available animal models–mammalian models for aging are relatively long-lived and aren’t as easily studied as shorter-lived species.

Resveratrol is an organic compound naturally present in grapes–and particularly enriched in red wine–and was previously shown to prolong lifespan in non-vertebrate model organisms such as yeast, the worm C. elegans, and the fruit fly Drosophila. However, until now, life-long pharmacological trials were performed in the worm or fly model organisms because of their very small size, very short natural lifespan, and affordable cultivation costs. Laboratory mice, on the other hand, live more than two years and are relatively expensive to maintain, making large-scale, life-long pharmacological trials in mice unaffordable.

Recently, a small fish species with a captive lifespan of only three months was described by Cellerino and colleagues. In the new work, the researchers used this short-lived fish to test the effects of resveratrol on aging-related physiological decay. The researchers added resveratrol to daily fish food and found that this treatment increased longevity and also retarded the onset of aging-related decays in memory and muscular performance.

Resveratrol appears to be the first molecule to consistently cause life extension across very different animal groups such as worms, insects, and fish, and it could become the starting molecule for the design drugs for the prevention of human aging-related diseases.

The researchers include Dario R. Valenzano of Scuola Normale Superiore in Pisa, Italy; Alessandro Cellerino of Scuola Normale Superiore and Istituto di Neuroscienze del CNR in Pisa Italy; Eva Terzibasi and Tyrone Genade of Istituto di Neuroscienze del CNR in Pisa Italy; Antonino Cattaneo of European Brain Research Institute and Lay Line Genomics S.p.A. in Rome, Italy; Luciano Domenici of Istituto di Neuroscienze del CNR in Pisa, Italy and Universita dell’Aquila in L’Aquila, Italy. This work was financed by Lay Line Genomics S.p.A., which holds the rights for commercial exploitation of the model.

Valenzano et al.: “Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate.” Publishing in Current Biology 16, 296-300, February 7, 2006. DOI 10.1016/j.cub.2005.12.038. www.current-biology.com


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The published research is quite definitive in that there are health benefits associated with intermittent fasting.

Most individuals who engage in intermittent fasting will typically skip breakfast and some will also skip lunch and eat later in the day.

For myself, I have found that skipping dinner – the evening meal seems to work better, so when I am intermittent fasting I will fast from lunch until breakfast the next morning.

There has been some discussion on this topic in our forum and it has been suggested by some that skipping breakfast may have negative effects on health.

I have reviewed some published research which supports this concept.

Following is an article written by Jacob Schor, ND, FABNO published in the Natural Medicine Journal which suggests that skipping breakfast may increase the risk of cardiovascular issues as well as all-cause mortality.

Perhaps it is time that we reconsider our personal protocols and patient recommendations regarding which meals to skip for intermittent fasting.

Results of a prospective cohort study

By Jacob Schor, ND, FABNO

Reference

Rong S, Snetselaar LG, Xu G, et al. Association of skipping breakfast with cardiovascular and all-cause mortality. J Am Coll Cardiol. 2019;73(16):2025-2032.

Study Objective

The authors examined the association of skipping breakfast with cardiovascular and all-cause mortality.

Design

This is a prospective cohort study. Frequency of eating breakfast was compared to cardiovascular and all-cause mortality risk using weighted Cox proportional hazards regression models.

Participants

The study followed a cohort of 6,550 US adults, 40 to 75 years of age, who participated in the National Health and Nutrition Examination Survey III 1988 to 1994. Frequency of breakfast eating was recorded during an in-house interview. Death and underlying causes of death were ascertained by linkage to death records through December 31, 2011.

Key Findings

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Of note with these types of studies:

Observational studies are of course problematic and despite the fact that the authors of the study took into consideration many potential confounders there are lots that were left out which could influence the outcomes and the list would be long: SNPs (polymorphisms), environmental toxins, hormone dysregulation, what kind of foods individuals were eating, circadian rhythm disturbances, exposure to blue light in the evening etc.

Issues such as this make nutrition/diet studies difficult to draw definitive conclusions from.

Well here we are in Canada over one year now since marijuana was legalized.

The potential medical benefits of marijuana consumption are significant however due to the historic U.S. government attitude towards drugs published research has not been very extensive.

Here are a couple of good resources which I use when discussing the potential medical benefits of marijuana:

Project CBD is an excellent research oriented resource on the science and application of CBD:

ProjectCBD

Here is a link to their Science page

NORML– National Organization for the Reform of Marijuana Legislation

This is a U.S. based lobbying organization which has for over 40 years been working to change legislation relating to marijuana – both for recreational use as well as medical use.

There is one particular pageon this website which does a good job of outlining the potential medical applications of marijuana – copied below.

I am not consuming any marijuana compounds currently however I have personally used marijuana products at certain times  over the past 15 years to help to manage a chronic pain condition.

I don’t currently need it as I am able to manage this condition with my own developed pain/inflammation formulation.

When I was using it in recent years, I would use a CBD tincture which worked quite well without any psychoactive effects from THC.

Before CBD fractions became available, I tried using a THC/CBD tincture formulation for my pain condition.  I was hoping that by being able to titrate the dosage that I could manage the psychoactive effects while achieving the pain/inflammation benefits but I had to abandon this strategy as I found the psychoactive effects too profound when I was working (something about trying to work on complex spreadsheets while feeling “buzzed” did not work!)

Today I want to share with you an article and a new study that suggests that chronic smoking of marijuana over a protracted period of time can increase the potential of developing testicular cancer in men by some 36%.

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Weight Watchers has just announced new meal plan with “more choice”- including unlimited pasta, rice, oatmeal and potatoes!

Eating unlimited amounts of the wrong types of carbohydrates is a recipe for Diabesity – and a spectrum of other health issues!