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Today I want to share with you an article which appeared today in the weekly Fight Aging newsletter.

The Fight Aging newsletter is free and is published and sent out weekly on Sundays.

It is the best source I know of as a summary of current developments in the area of aging research.

This article discusses the concept that age-related degeneration of joints – specifically cartilage is associated with inflammation, which I am sure for most of you is a well known basic concept.

It mentions two key concepts: the Inflammasome as well as Cellular Senescence.

If you are not familiar with the concept of the Inflammasome I have included a link and abstract from a paper published in Nature at the end of this article.

Regarding cellular senescence, I have previously written an article on this topic in October of last year –

Here is a link to the article if you want to review it.

Cellular senescence has been identified as a key factor contributing to the aging process, and it is a key target for both big Pharma as well as Biotech companies to develop compounds which target and destroy senescent cells – referred to as “Senolytics”.

There are currently human drug trials being conducted with senolytic compounds to target senesecent cells (sometimes referred to as “zombie cells” in the common literature) and  I am of the opinion that awareness of this concept will be well established within the general population within probably 12 – 24 months – and I don’t think there is any doubt that health care practitioners across the spectrum will be utilizing senolytic compounds in their practice to target age related degenerative conditions.

Our Activity Relating to Senolytics

I have been extensively researching this topic of cellular senescence and senolytic compounds for approximately two years now and our company is in the final stages of application preparation for an NPN for a natural source senolytic formulation,
so hopefully within about six months or so we will have our formulation approved such that we can bring it to the market:

I will provide you with further information on this topic as we progress towards our product launch.

To my knowledge, at this stage there are no specific natural compound formulations which target cellular senescence – anywhere in the world.

Following is the article: one key takeaway from this article and additional reading I have done on this topic is that senolytic compounds may provide a key approach to arthritic conditions.

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I wrote a newsletter article several years ago documenting an apparent link between a common parasitic infection sourced from cats – toxoplasmosis and schizophrenia.

Further evidence of this link has been shown with the recent publication of a large cohort study – over 80,000 individuals done in Denmark.

Results from the study suggested that infection from not only Toxoplasma gondii but also CMV – Cytomegalovirus may be responsible for an increased incidence of schizophrenia as well as other conditions  including a range of neurological disorders, including epilepsy, Alzheimer’s, and Parkinson’s, among others – as well as potentially increasing suicide rates.

This correlation has been suspected and documented in previous published research (see links at the end of this article) however this study was the first one to examine ‘temporality’ – which meant only looking at participants who hadn’t yet been diagnosed with schizophrenia when T. gondii was found in their blood.

“The association was even stronger when accounting for temporality and considering only the 28 cases who were diagnosed with a schizophrenia disorder after the date of blood collection,” the authors write.

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Today I wanted to share with you an article published on the Green Med Info website and the referenced study published in JAMA Paediatrics which suggests that the consumption of acetaminophen by women  during pregnancy is more likely to result  in a child having ADHD as well as a higher risk of having children who exhibit other emotional or behavioral symptoms.

The article also points out that acetaminophen is very hard on the liver – about 40% of regular acetaminophen users show signs of liver damage. Acetaminophen reduces the liver’s store of the important detoxifying aid and antioxidant glutathione.

Also consumption of acetaminophen during the first year of life can increase the potential for developing asthma.

There are many safe natural alternatives to acetaminophen: Michael Murray, ND the article’s author suggests ginger as a viable alternative.

In my opinion acetaminophen with all its potential negative health effects and limited benefits should not be consumed.

A REMINDER:

Our Integra Nutrition Longevity Sciences formulation GenZogenol-R will be available within one week.

GenZogenol-R is a formulation developed to directly target some of the causes of aging at the DNA level.

Here is a link to an overview of this exciting formulation

Following is the article and the referenced journal abstract.

Regards,

Rob

Another damning study indicates it is simply time to pull the plug on this outdated drug.

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The Dangers of Drinking Sodas

Great article from Organic Lifestyle Magazine on the dangers of drinking soda drinks:

“Soda is proven to be addictive and consumption has been clinically linked to increased blood pressure, high blood sugar, weight gain, kidney disease, heart disease, diabetes, depression, asthma, headaches, ear infections, joint and muscle problems, developmental delays, ADHD, heavy metal toxicity, yeast infections, urinary tract infections, candidiasis, other increased pathogenic activity, increased PMS symptoms, brain damage, liver toxicity, tooth decay, acne, mood swings, decreased fertility in men and women, and so much more!

In other words, drinking soda feeds infections, disrupts the gut microbiome and the metabolic processes, degrades cells, causes chronic illness, exacerbates virtually all chronic illness symptoms, and rapidly ages the body.”

Read More:

If You Drink Soda, It’s Probably The Worst Thing You Do To Yourself (even worse than smoking!)

Starting fifteen years ago, I was unfortunately involved in a number of car accidents which extended over a period of ten years.

My second accident in which I got rear ended resulted in an upper cervical misalignment issue the result of which was that my atlas impinged upon on my spinal cord.

The outcome of this trauma was that I started experiencing intractable pain and I went from being very active to not being able to sit down for more than 20 minutes without my back going into spasm and twisting out of shape.

Thus began a five year journey to try to determine a diagnosis – and to develop a therapeutic protocol that would help me to progress towards recovering my health.

Some of the readers of this newsletter were involved in helping me on this healing journey of discovery – and I thank them for their efforts.

The level of pain was so significant that I had to start taking opoids – which initially made me violently ill as I had never taken prescription drugs of this nature: I even ended up having to take Oxycocet – a slow release form of Oxycodone.

Needless to say, this created significant side effects in terms of brain fog, constipation – and I was unlucky in that there is a subset of the population that react paradoxically to codeine in that they do not experience a sedative effect but rather a stimulatory effect.

Most opoids are combined with caffeine: so I got versions of the meds without caffeine, but the stimulatory effects did not diminish.

This started impacting on my sleep so as a result I needed to start taking Zopiclone: the “little blue pill” – which is highly addictive, which is what happened to me over time.

After this accident, I started experiencing debilitating weekly migraine headaches: I experienced an aura the first time I got one but that was the only time.

A number of years ago, a prescription drug for migraines was developed which revolutionized treatment: Sumatriptan. A number of variations on this molecular configuration appeared on the market and this class of drugs is now referred to as “Triptans”.

And I was fortunate: Sumatriptan kicked in within sixty minutes and completely got rid of the migraine with almost no side effects.  Mind you, it was costing me approximately $14.00 per pill – however when you are experiencing a migraine you would pay almost any price for relief.

I finally figured out what my issue was as a result of the accident, specifically that my atlas had become misaligned.

You may be familiar with the fact that there is a sub-specialty in the chiropractic profession – Upper Cervical in which the practitioner is certified through the NUCCA organization – National Upper Cervical Chiropractic Association

Some of the readers of this newsletter specialize in this technique in their practices.

Upper Cervical treatments proved to be what I needed to resolve my significant, acute pain condition: it took time but this was the core issue.

This did not however resolve the frequency of my migraines: I was determined to figure this out because despite the fact that the Triptans worked well, I did not relish paying $14.00 a pill on an ongoing basis to resolve the symptoms of my condition – rather than the cause.

Like most who read this newsletter, I was familiar with all the potential food and drink compounds which could potentially initiate migraines so I put myself on an elimination diet – but that only accounted for approximately 10% resolution – as a result of alcohol.

I was fortunate at this time to develop a friendship with a local IFM (Institute of Functional Medicine) MD – Helen Messier.  Helen was actually a faculty member with the IFM and she not only had functional medicine expertise but prior to doing her MD training she had done a PhD which gave her an expert understanding of genomics – and SNPs (single nucleotide polymorphisms – genetic mutations).

With her guidance – and my own ability to review the literature and learn about health topics on my own, I developed a knowledge of this complex topic – rudimentary for sure but certainly enough to enable me to figure out what was going on with respect to the migraine headaches I was contending with.

I am sure most reading would now be familiar with methylation pathway issues – and some of the key SNPs related to this such as MTHFR – Methylenetetrahydrofolate reductase.

Here is a quick explanation from Chris Kresser on the functions of this key enzyme:

(MTHFR) is the rate-limiting enzyme of the methyl cycle; it is responsible for the activation of folate for the subsequent reduction of homocysteine to methionine (1) . Certain single nucleotide polymorphisms (SNPs), or variants of this gene, result in the reduced capacity of this enzyme (2). Indeed, MTHFR variants are associated with increased risk for many diseases, including depression, fertility issues, insomnia, and thyroid conditions (3).

This mutation is present in approximately 40% of the general population – so it is very common.

I was dealing with some of the consequences of this SNP – but there was also another issue: histamine degradation.

The specific enzyme that breaks down histamine is named: Diamine Oxidase – DAO.

It became apparent that I had some degree of deficiency in this key enzyme.

As a result of these two factors, it was initiating my weekly migraines –

SO HERE IS THE BIOHACK THAT I IMPLEMENTED TO RESOLVE THIS ISSUE:

A number of the practitioner grade supplement product companies provide formulations which are described as: “Methyl Donors and Accepters”.

A couple of products that I have used are supplied by Biotics Research and Xymogen.

The Biotics formulation is called: Oorganik-15.

I started taking this product on a daily basis and as well Xymogen have a product available which provides the enzyme that breaks down histamine: HistDAO.

I also started taking this formulation several times a week: I experimented to determine the minimally effective dosage as it is expensive: approximately $40.00 wholesale.

I also started taking taking an MTHF (methyltetrahydrofolate) formulation to make up for my methylation pathway issues.

And the results:

My migraine frequency decreased by over 95% overnight!

It changed my life – for the better of course.

One further biohack that I have since utilized which actually allowed me to stop taking the HistDAO is I got my metabolism to the state whereby it is metabolically flexible and I spend most of my time in a ketogenic state.

Ketosis can be beneficial for the prevention and mitigation of headaches.

So there you have it – my most significant personal biohack.

Will this protocol work for yourself and/or your patients?

It is hard to say however it is certainly an inexpensive biohack to remember that you can try…

I have determined through my own personal biohacking experimentation that a ketogenic diet is an optimal diet for my metabolism.

In fact what most people refer to as a ketogenic diet is more appropriately described as a modified Atkins diet as a strict ketogenic diet, such as that which is used for children with uncontrolled seizures typically consists of a diet which is composed of approximately 80% fat content which would be very difficult for the average person to follow.

The key to the metabolic benefits of ketosis is developing a state of metabolic flexibility such that the metabolism can switch back and forth effortlessly between burning fat (ketone bodies) and sugar – rather than getting hung up on the depth of ketosis.

And I am not fanatical about staying in ketosis – again the key is being able to effortlessly shift back and forth between burning fat and sugar.

One breakfast meal I will occasionally consume – which is certainly not ketogenic consists of organic berries (I will not consume non organic berries as they are one of the most extensively sprayed foods) with some organic yogurt topped with some seeds and nuts (pumpkin, sunflower, hemp hearts etc.) with a little drizzle of oil on top (typically avocado oil) – and a touch of nut milk.

To this meal I will ALWAYS add some pomegranate – and this is the topic of today’s newsletter.

Pomegranate provides many health benefits – listed below however what I wanted to focus on in this article is the substantial cardiovascular benefits provided by pomegranate.

Following is an article from the Green Med Info website, as well as the abstract from the referred to study.

Here is an outline of some of the various health benefits of pomegranate from an article on the Stylecraze website:

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